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Cardiovascular and Metabolic Disease: These fireworks and balloons are fatty cells. Credit: Vanessa Schmidt (Lab of Thomas Willnow) Cancer Research: The colorful confetti of tumor cells which has been stained Credit: Matthias Leisegang (formerly Lab of Wolfgang Uckert) Research Report 2016 (covers the period 2014-2016) Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Communications Department Robert-Rössle-Str.10 13125 Berlin Phone: -0 Email: [email protected] Research Report is also available online: of the Nervous System: Under the microscope the cross-section of mouse skeletal muscle looks has a sponge-like structure.Insulin receptors appear red and early endosomes green. Muscle stem cells stained by an antibody against Pax7 (blue) are located under the basal lamina (green).During the last two years, two new drugs have reached the market in Eu- rope and the United States that represent entirely new therapeutic principles based on research at the MDC: the cancer drug Blincyto and a new treatment for bleed- ing disorders, VONVENDI.We are proud of these recent successes and constantly strive for new opportunities.We also hope that it conveys some of the fascination and excitement that charac- terize our work.The second example is single-cell biology, worldwide project that will rival the Hu- man Genome Project in scale.Credit: Christin Stottmeister (Lab of Nikolaus Rajewsky) ECRC: This image depicts human myoblasts and myotubes derived from a biopsy.

Indeed, highly in- terdisciplinary work has long been a hall- mark of MDC science.

Image Captions are actually induced pluripotent stem cells in a pluripotency test.

The cells are Credit: Gizem Inak (Lab of Erich Wanker, Group of Alessandro Prigione) Cover: What looks like coral reefs and brightly glowing fishes in this picture stained with a fluorescent dye (Lin28-DAPI).

elegans Baris Tursun 208 Systems biology of neural tissue differentiation Robert P.

Zinzen 211 The Experimental and Clinical Research Center (ECRC) Friedrich C. Exploring these mechanisms and transla- Life in our labs deals with fundamental questions of health and disease, while at the same time focusing on small details – such as the intricate workings of an organ- ism, a cell and even an ion channel or recep- seem abstract.

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Rathjen 162 Role of GPRIN1 on kainate-receptors function Dietmar Schmitz 164 Proteomics and Molecular Mechanisms of Neurodegenerative Diseases Erich Wanker 168 Development and Function of Neural Circuits Niccolò Zampieri 171 Berlin Institute for Medical Systems Biology Nikolaus Rajewsky 174 BIMSB Bioinformatics / Mathematical Modelling Altuna Akalin 176 Non-coding RNAs and mechanisms of cytoplasmic gene regulation Marina Chekulaeva 178 Quantitative developmental biology Jan Philipp Junker 180 Dynamics and functions of the enhancer landscape during zebrafish development and cardiogenesis Scott Lacadie 182 RNA Biology and Posttranscriptional Regulation Markus Landthaler 184 RNA Structure and Transcriptome Regulation Irmtraud M.

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